NKTR-061 (inhaled amikacin) delivers high lung doses in mechanically ventilated patients with pneumonia and in healthy subjects
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia
INTRODUCTION Aminoglycosides aerosolization might achieve better diffusion into the alveolar compartment than intravenous use. The objective of this multicenter study was to evaluate aerosol-delivered amikacin penetration into the alveolar epithelial lining fluid (ELF) using a new vibrating mesh nebulizer (Pulmonary Drug Delivery System (PDDS), Nektar Therapeutics), which delivers high doses to...
متن کاملHigh Dose Nebulized Amikacin: a Pilot Study in Ventilated Patients with Healthcare Associated Pneumonia
cytokines determination was used ELISA. RESULTS. 41 patients were included, 11 (26 %) developed VAP. APACHE II 24 ± 7. Development of VAP was associated with higher ICU stay, time under MV and mortality. Baseline Those who developed VAP presented worst pO2/FiO2 ratio 152 vs 259 (p \ 0.01). In 24 % of patients was identified a microorganism, (26 % of non-VAP patients and 18 % in VAP-patients, in...
متن کاملSizing the lung of mechanically ventilated patients
INTRODUCTION This small observational study was motivated by our belief that scaling the tidal volume in mechanically ventilated patients to the size of the injured lung is safer and more 'physiologic' than scaling it to predicted body weight, i.e. its size before it was injured. We defined Total Lung Capacity (TLC) as the thoracic gas volume at an airway pressure of 40 cm H2O and tested if TLC...
متن کاملthe past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
Bronchoscopy in Mechanically Ventilated Patients
The origins of bronchoscopy date back to 1897 when Gustav Killian, considered “the father of bronchoscopy”, performed the first airway examination with a rigid esophagoscope to a farmer extracting a piece of bone that had lodged in the main stem bronchus. Shigeto Ikeda in 1964 revolutionized the field of bronchoscopy with the introduction of a flexible instrument that could be introduced to sub...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2008
ISSN: 1364-8535
DOI: 10.1186/cc6263